Intrarenal localization of angiotensin II type 1 receptor mRNA in the rat
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چکیده
منابع مشابه
Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.
ATRAP [ANG II type 1 receptor (AT1R)-associated protein] is a molecule which directly interacts with AT1R and inhibits AT1R signaling. The aim of this study was to examine the effects of continuous ANG II infusion on the intrarenal expression and distribution of ATRAP and to determine the role of AT1R signaling in mediating these effects. C57BL/6 male mice were subjected to vehicle or ANG II in...
متن کاملRegulation of angiotensin II type 1 receptor mRNA and protein in angiotensin II-induced hypertension.
Chronic elevations of circulating angiotensin II (Ang II) cause sustained hypertension and enhanced accumulation of intrarenal Ang II by an AT1 receptor-dependent process. The present study tested the hypothesis that chronic elevations in circulating Ang II regulate AT1 mRNA and protein expression in a tissue-specific manner. Sprague-Dawley rats were infused with Ang II (80 ng/min) or vehicle s...
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Intrarenal Perfusion and Angiotensin II Levels Regulate In Vivo Angiotensin II Type 1 Receptor Imaging in the Kidney To the Editor: In the recent issue of Hypertension, Dr Szabo’s group used novel positron-emission tomographic (PET) [C]KR31173 imaging to study the regulation of intrarenal angiotensin II type 1 (AT1) receptor binding in a swine model of renal artery stenosis in vivo.1 In this st...
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Recent studies suggest a crucial role of reactive oxygen species (ROS) for the signaling of angiotensin (Ang) II through Ang II type 1 receptor (AT(1)-R). However, the role of ROS in the regulation of AT(1)-R expression has not been explored. In this study, we examined the effect of an antioxidant on the homologous downregulation of AT(1)-R by Ang II. Ang II (10(-6) mol/L) decreased AT(1)-R mRN...
متن کاملRenal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat.
Whereas angiotensin (Ang) II is the major effector peptide of the renin-angiotensin system, its metabolite, des-aspartyl1-Ang II (Ang III), may also have biologic activity. We investigated the effects of renal interstitial (RI) administration of candesartan (CAND), a specific Ang II type 1 receptor (AT1) blocker, with and without coinfusion of PD-123319 (PD), a specific Ang II type 2 receptor (...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1993
ISSN: 0085-2538
DOI: 10.1038/ki.1993.174